What signs and symptoms can one observe in a case of barbiturate abuse?

Signs and symptoms of barbiturate abuse can include:

Physical:

- Slowed breathing

- Low blood pressure

- Drowsiness

- Impaired coordination

- Slurred speech

- Nystagmus (involuntary eye movements)

- Coma

Behavioral:

- Disinhibition

- Impulsivity

- Risk-taking behaviors

- Irritability

- Confusion

- Memory loss

- Hallucinations

- Suicidal thoughts or behaviors

In severe cases, barbiturate abuse can lead to respiratory depression, cardiac arrest, and death.