Excedrin PM Dosage Warnings: Acetaminophen Limits, Allergies, Side Effects, and Interactions

Excedrin PM = Acetaminophen 250 mg + Aspirin 250 mg + Caffeine 65 mg + Diphenhydramine 38 mg (per caplet). Not standard Excedrin PM formulation; verify label.

Critical Safety Limits

• Acetaminophen: Max 3000–4000 mg/24h (all sources). Liver failure risk with overdose.
• Aspirin: Avoid in children/teens (Reye's), bleeding disorders, ulcers, anticoagulants.
• Diphenhydramine: Sedation, anticholinergic effects (confusion, urinary retention in elderly).
• Caffeine: May worsen anxiety, insomnia, tachycardia.

Key Warnings

• Do not combine with other acetaminophen/NSAID/sedating products.
• Max 2 caplets/24h (per some labels); follow package instructions exactly.
• Avoid alcohol.
• Pregnancy: aspirin contraindicated 3rd trimester; consult OB.

Read label. Ask pharmacist/doctor if unsure.