Meridia (Sibutramine): Side Effects, Uses & Warnings

Meridia (sibutramine hydrochloride monohydrate) is prescribed to achieve and maintain weight loss in obese patients. It is intended and recommended for patients with a body mass index (BMI) greater than 30, or 27 if other health risks are present. Like most medications, some side effects are possible if you take Meridia.

Function

• Meridia works by inhibiting the reuptake of the neurotransmitters serotonin, dopamine and norepinephrine, which are chemicals of the brain that affect hunger.

Common Side Effects

• Common side effects include sleep disruption, dry mouth, headache, loss of appetite and constipation.

Serious Side Effects

• Serious side effects that have been reported include seizures, bleeding, an increase in blood pressure or heart rate, and a rare condition called "serotonin syndrome," which can be life threatening. According to the Food and Drug Administration, reported allergic reactions include hives, angioedema and anaphylaxis.

Warning

• According to the FDA, blood pressure and/or pulse rate can significantly increase in some patients. Blood pressure and pulse rate should be monitored while taking Meridia.

Consideration

• Meridia is classified and controlled as a Schedule IV drug under the Controlled Substances Act. Abuse may lead to limited physical or psychological dependence.