What is the difference between localized and systemic scleroderma?

Localized scleroderma:

- Also called morphea

- Affects only the skin

- Can cause skin to become hard, thick, and discolored

- May also cause itching and pain

- Most common in children and young adults

- Usually treated with topical medications, such as corticosteroids or calcipotriene

- Prognosis is generally good, with most people experiencing complete remission within a few years

Systemic scleroderma:

- Also called scleroderma or progressive systemic sclerosis (PSS)

- Affects the skin, internal organs, and blood vessels

- Can cause skin to become hard, thick, and discolored

- May also cause joint pain, muscle weakness, fatigue, and shortness of breath

- Most common in women between the ages of 30 and 50

- Usually treated with systemic medications, such as corticosteroids, methotrexate, or mycophenolate mofetil

- Prognosis is variable, but most people with systemic scleroderma can live a normal life with treatment