Thalassemia and Hepatomegaly: Understanding the Liver Connection

In thalassemia, ineffective erythropoiesis produces defective red cells that are destroyed early, causing iron overload. The liver, the primary iron-metabolizing organ, becomes overloaded and enlarges (hepatomegaly).

Contributing Factors

• Increased hepatic blood flow
• Portal hypertension
• Cholestasis (impaired bile flow)

Iron overload is the main driver; managing iron levels is crucial to limit liver damage.