Medications That Can Impact Prostate-Specific Antigen (PSA) Levels

PSA stands for prostate specific antigen. It is often used as a screening test to detect prostatic cancer. PSA levels can also be elevated due to a condition known as benign prostatic hypertrophy or due to certain activities, such as bicycle riding. Additionally, PSA levels can be affected by various medications.

Finasteride

• One medication that can affect PSA levels is finasteride, which goes by the brand name Proscar or Propecia. This medication can cause your PSA levels to be decreased.

Dutasteride

• Dutasteride, also called Avodart, is a medication for benign prostatic hyperplasia. It can result in lower than normal PSA levels.

Cyclophosphamide

• Cyclophosphamide is an alkylating agent used to treat some kinds of cancers. High doses can alter PSA levels, causing them to be elevated.

Methotrexate

• Methotrexate is a chemical compound often used to suppress the immune system in order to treat certain cancers and for transplant patients. It can also lead to altered PSA levels.

Viagra and Cialis

• Viagra and Cialis, while not directly affecting PSA levels, do promote sexual activity. Recent ejaculation (within 48 hours of the test) can cause PSA levels to be elevated.