Nephrology: Kidney Diseases, Diagnosis & Treatment Overview

What Is Nephrology?

Nephrology is the internal medicine subspecialty focused on kidney function, disease, and systemic consequences of renal dysfunction.

Conditions Managed

  • Glomerulonephritis: Inflammatory glomerular injury (immune, infectious, systemic).
  • Pyelonephritis: Kidney infection (usually ascending UTI).
  • Nephrolithiasis (Kidney Stones): Calcium oxalate, uric acid, struvite, cystine.
  • Chronic Kidney Disease (CKD): Stages 1–5 by eGFR; progression slowing, complication management.
  • End-Stage Renal Disease (ESRD): Dialysis (HD/PD) and transplant coordination.
  • Electrolyte/Acid-Base Disorders: Hyperkalemia, metabolic acidosis, etc.
  • Hypertensive Nephrosclerosis / Diabetic Nephropathy: Leading CKD causes.

Diagnostic Tools

  • Urinalysis: Protein, blood, casts, pH, specific gravity.
  • Blood Work: Creatinine, BUN, eGFR, electrolytes, bicarbonate, CBC.
  • Imaging: Renal US (size, obstruction, cysts), CT/MRI for masses/vascular.
  • Biopsy: For glomerular disease diagnosis.

Treatment Modalities

  • Medications: ACEi/ARB, SGLT2i, immunosuppressants, diuretics, binders.
  • Dietary: Sodium, potassium, phosphate, protein modulation.
  • Renal Replacement: Hemodialysis, peritoneal dialysis, kidney transplant.
  • Multidisciplinary: Cardiology, endocrinology, vascular surgery, dietetics, social work.

Nephrologists are central to preserving kidney function and managing the systemic effects of kidney failure.

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