Celiac Disease Risk: Understanding Genetic Predisposition and Family Links
Celiac disease has a strong genetic component. Relatives of affected individuals are at increased risk because they may inherit predisposing genetic variants, notably HLA-DQ2 and HLA-DQ8 (involved in immune response to gluten).
Environmental factors also matter: timing/amount of gluten exposure, infections, stressors.
If you have a close relative with celiac disease, discuss testing with your doctor, even if asymptomatic.
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