Syphilis Reinfection: Yes, You Can Get It Again

Syphilis reinfection is possible and common. Treatment (penicillin) cures the current infection but does not confer lasting immunity. Re-exposure to Treponema pallidum through unprotected sex with an infected partner can cause a new infection.

Prevention:

  • Consistent condom use.
  • Regular STI screening (especially with new/multiple partners).
  • Partner notification and treatment after diagnosis.
  • Abstinence during treatment and until sores heal.

Follow-up testing (RPR/VDRL titers) at 6 and 12 months post-treatment confirms cure. A fourfold titer rise suggests reinfection or treatment failure.

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