IVIG and Live Vaccines: Required Interval
Intravenous immunoglobulin (IVIG) contains high-titer antibodies that neutralize live-attenuated vaccines (MMR, varicella, yellow fever, oral polio, rotavirus, nasal influenza).
Recommended Intervals
- IVIG → Live vaccine: Wait 3–11 months (depends on dose; 8 months for standard 2 g/kg).
- Live vaccine → IVIG: Wait ≥2 weeks if possible.
Inactivated vaccines are unaffected. Check CDC/ACIP guidelines for specific products and doses.
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