Fetal Antibodies & Maternal Health: No Direct Harm
Fetal antibodies cannot harm the mother. Maternal and fetal circulations are separated by the placental barrier. While IgG crosses placenta (mother→fetus), fetal IgM/IgG do not cross back in significant amounts. Fetal immune responses remain confined to fetal compartment.
Exceptions: Rh/ABO alloimmunization involves maternal antibodies against fetal antigens—not fetal antibodies attacking mother.
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