Leukocytes Responsible for Histamine Release & Inflammation

Mast cells and basophils are the leukocytes responsible for releasing histamine and other mediators of inflammation.

Mast cells are located in connective tissues, while basophils are found in the blood. Both cell types contain granules that store histamine, as well as other inflammatory mediators such as tryptase, chymase, and leukotrienes.

When mast cells and basophils are activated, they release their granules into the surrounding environment. This can cause a number of inflammatory symptoms, including:

* Vasodilation (widening of blood vessels)

* Increased vascular permeability (leakage of fluid from blood vessels)

* Smooth muscle contraction (which can lead to bronchoconstriction, for example)

* Pain

* Swelling

* Redness

* Heat

Mast cells and basophils play an important role in the body's response to injury and infection. However, their activation can also lead to allergic reactions and other inflammatory disorders.