Possible Causes of Your Symptoms: Tender Breasts, Fatigue, and More

There are a number of possible explanations for your symptoms, including:

- Pregnancy: Even though you have had three negative first response tests, it is still possible that you could be pregnant. Sometimes, pregnancy hormones can take longer to build up in the urine, so it may be worth taking another test in a few days or weeks.

- Premenstrual syndrome (PMS): PMS can cause a variety of symptoms, including tender breasts, tiredness, nausea, and acne. If your period is late, it is possible that you are experiencing PMS.

- Other medical conditions: Certain medical conditions, such as thyroid problems, can also cause symptoms similar to those you are experiencing. If you are concerned about your symptoms, it is worth seeing a doctor for evaluation.

In the meantime, there are a few things you can do to help relieve your symptoms:

- Get plenty of rest.

- Eat a healthy diet.

- Exercise regularly.

- Reduce stress.

- Take over-the-counter pain relievers, such as ibuprofen or acetaminophen, to relieve any pain or discomfort.

If your symptoms do not improve, or if you have any concerns about your health, be sure to see a doctor.