Sertoli Cells & Male Hormones: ABP and Inhibin Explained

The two primary hormones produced by Sertoli cells in an adult male are:

1) Androgen-Binding Protein (ABP): ABP is a glycoprotein that binds to testosterone, the primary male sex hormone, within the seminiferous tubules. This helps maintain a high local concentration of testosterone, which is crucial for spermatogenesis. ABP also transports testosterone to the epididymis, where it is essential for the maturation and transport of sperm.

2) Inhibin: Inhibin is a peptide hormone that plays a crucial role in regulating the production of follicle-stimulating hormone (FSH) by the pituitary gland. FSH stimulates Sertoli cells to produce ABP and is also involved in the regulation of spermatogenesis. Inhibin acts as a negative feedback mechanism, suppressing the release of FSH when the levels of inhibin are high.

Both ABP and inhibin are produced and secreted by Sertoli cells, which are located in the seminiferous tubules of the testes. These hormones are important for maintaining normal spermatogenesis, regulating testosterone levels, and controlling FSH secretion, thereby contributing to male reproductive health and fertility.