| | Conditions & Treatments | Herpes What temperature will kill herpes virus? The herpes simplex virus (HSV), which causes both oral and genital herpes, can be inactivated by temperatures of 50°C (122°F) or higher for 30 minutes. Herpes - Related Articles About Cold Sore Relief Herpes Treatment During Pregnancy Homeopathic Cures for Fever Blisters What is a sign of herpes in male? Facts About the Herpes Virus What Do Herpes Test Numbers Mean? Effects of the Herpes Virus