Wellbutrin and Liver Health: What You Need to Know

Wellbutrin (bupropion) is generally well-tolerated by the liver. Metabolized via CYP2B6; doesn't typically cause significant liver damage.

Common Liver-Related Side Effects

1. Mild, transient ALT/AST elevations.
2. Nausea/vomiting (early treatment, usually subsides).
3. Abdominal pain (less common).

Rare Severe Effects

Hepatitis or liver failure—very uncommon, usually in those with pre-existing liver disease or on other hepatotoxic drugs.

Discuss concerns with your doctor; they can monitor liver function and adjust treatment if needed.