Interferon for Hepatitis C: Ocular Risks & Complications

Serious Ocular complications seen in patients treated with interferon for Hepatitis C include:

Macular Edema: Occurs in 5%-20% cases. It manifests as metamorphopsia, blurred vision, and microcystoid macular edema. Management involves decreasing the interferon dose, laser treatment, or intravitreal injections.

Retinal Hemorrhages: Most often found around the optic nerve. Visual loss may occur due to macular hemorrhage. Treatment includes anti-VEGF and observation.

Cotton Wool Spots: Associated with profound anemia and thrombocytopenia.

Ischemic Optic Neuropathy: It is a severe complication associated with interferon. Visual loss may be partial or complete. There is no specific treatment.

Epiretinal Membranes: Often detected by Optical Coherence Tomography. They are generally asymptomatic and do not require treatment.