CPT Codes for Factor XII (Hageman Factor) Assays and Bleeding Workup

There is no single CPT code for "Factor XII excessive bleeding, menopausal onset." Factor XII deficiency is typically asymptomatic (prolongs aPTT but not bleeding); bleeding at menopause suggests other pathology.

Relevant Codes

• 85384 – Coagulation factor assay, each factor (use for Factor XII activity/antigen).
• 85385 – Factor inhibitor assay (if acquired inhibitor suspected).
• 85007 – Bleeding time (rarely used now).
• 85347 – Coagulation time, activated (ACT).
• 85378 – Fibrin degradation products (D-dimer).
• 85576 – Platelet aggregation (if platelet dysfunction considered).
• 28299 – Unlisted lab procedure (last resort).

Clinical Note

Isolated Factor XII deficiency does not cause clinical bleeding. Evaluate for vWD, platelet dysfunction, hormonal changes, or malignancy if bleeding is new at menopause.