Psoriasis Treatment Options: Topical, Systemic, Phototherapy, and More

Treatment Approaches for Psoriasis

1. Topical Treatments

• Corticosteroids – reduce inflammation/itch (mild-moderate).
• Vitamin D analogues – slow skin cell growth.
• Calcipotriol (Dovonex) – synthetic vitamin D analogue.
• Coal tar – slows cell growth, reduces itch/inflammation.
• Salicylic acid – removes scales, enhances penetration.

2. Systemic Treatments

• Oral: Methotrexate, cyclosporine, retinoids (acitretin) – for moderate-severe; monitor side effects.
• Biologics (injections/infusions): Target specific immune pathways.
  • Anti-TNF-α: adalimumab, infliximab, etanercept
  • Anti-IL-12/23: ustekinumab
  • Anti-IL-17: secukinumab, ixekizumab, brodalumab
  • Anti-IL-23: guselkumab, risankizumab, tildrakizumab

3. Phototherapy

• UVB phototherapy – controlled UVB exposure.
• PUVA – psoralen + UVA.

4. Complementary Therapies

• Aloe vera gel – soothing, anti-inflammatory.
• Oatmeal baths – relieve irritation.

Effectiveness

Varies by individual and severity; combination therapy often needed. Consult a dermatologist for a tailored plan.