| | Conditions & Treatments | Digestive Health What part of the large intestine does small empty into? The small intestine does not empty into the large intestine. The small intestine empties into the large intestine. Digestive Health - Related Articles Is Grunting a Symptom of Acid Reflux? Does pumpkin pie cause acid reflux? How to Diet for Diverticulitis How to Use Nystatin for Ulcerative Colitis How to Easily Get Rid of Gas and Bloating Medication for GERD Side Effects of Imodium