| | Conditions & Treatments | Digestive Health What is the opening of digestive system? The opening of the digestive system is the mouth. The mouth is where food enters the body and begins the process of digestion. Digestive Health - Related Articles Colon Cleansing for Men How to Prevent Abdominal Adhesions GABA Benefits for Constipation Relief Where is digestion held in the Monera Kingdom? How to Manage Lactose Intolerance Crohn's Disease Treatment in Children What are the mixture of food and digestive juices called?