Endogenous Depression vs. Bipolar Disorder: Understanding the Differences

Endogenous and manic depressions are mood disorders that can be successfully managed with proper treatment. Unlike endogenous depression, manic depression is characterized by a swing between opposing poles of high and low mood. As with all depression, complications can occur and symptoms can adversely affect an individual's life.

Considerations

• Endogenous (unipolar) depression is considered to be a biological depression with no trigger or source. Manic depression, also known as bipolar disorder, is a psychiatric illness that is classified as a mood disorder and, likewise, has no known source.

Symptoms

• Depressive symptoms such as persistent feelings of sadness, weight fluctuation and anxiety are common to both unipolar and bipolar conditions. In the case of manic depression, the depressive symptoms give way to manic episodes. Mood swing cycling can be rapid or gradual.

Effects

• Both depressions can adversely impact an individual's social, familial and professional relationships and detrimentally affect self-esteem and self-image.

Treatment

• Endogenous depressions are treated with antidepressants and, in some cases, cognitive behavioral therapy (CBT). Manic depression is often treated with a combination of mood stabilizing medications and psychotherapy.

Complications

• Complications associated with both endogenous and manic depressions can include suicide, secondary medical conditions and medication noncompliance. In-patient, or residential, treatment may be required for intense therapy, to establish medication compliance and promote appropriate symptom management.