Direct HDL Cholesterol Test: What You Need to Know

Direct HDL is a laboratory test that determines the level of high-density lipoprotein (HDL) cholesterol by measuring directly in human serum, shortening turnaround time and saving labor costs, according to a study published in "Clinical Chemistry."

Significance

• A direct HDL test can be performed as part of a lipid profile, which checks for HDL, low-density lipoprotein (LDL) cholesterol and triglycerides, according to MayoClinic.com. Cholesterol tests are often performed to determine risk for heart disease.

Cholesterol Test

• According to the study in "Clinical Chemistry," the direct HDL test is a homogeneous assay, a laboratory chemical analysis designed to test a homogeneous organic sample, meaning it has a uniform composition and does not need to be separated into specific compounds. This simplifies HDL testing, according to the scientific journal.

Amount

• Direct HDL measures only HDL, which carries about 1/4 to 1/3 of blood cholesterol. HDL, LDL, triglycerides and another type of cholesterol called Lp(a) make up a total cholesterol count.

'Good' Cholesterol

• HDL cholesterol is called ̶0;good̶1; cholesterol because it carries cholesterol away from arteries and back to the liver, where it's broken down and eliminated, according to the American Heart Association.

HDL Levels

• Average HDL cholesterol levels range from 40 to 50mg/dL for men, according to the American Heart Association. For women, they range from 50 to 60mg/dL. A level of 60mg/dL or higher is beneficial for both women and men, according to the association. The higher the level, the better, MayoClinic.com information states.