| | Conditions & Treatments | Cholesterol Is there grapefruit in mello yello and will it interfear with my cholesterol meds...? Mello Yello does not contain grapefruit or grapefruit juice. Therefore, it will not interfere with your cholesterol medication. Cholesterol - Related Articles Symptoms of High Triglyceride Levels How Much Cholesterol Should One Consume Daily? Ways to Decrease LDL A Natural Remedy for Reducing Cholesterol How to Up Your HDL Levels Lipids in the Bloodstream How to Choose a Statin for High Cholesterol