Blood Type Compatibility: Can A+ and B- Create O-?

No, A positive and B negative blood types cannot produce O negative blood.

A person with A positive blood type has the A antigen on their red blood cells and the Rh factor (D antigen). A person with B negative blood type has the B antigen on their red blood cells but lacks the Rh factor. When these two blood types are mixed, the resulting blood type will have both A and B antigens and the Rh factor, making it AB positive blood type.

O negative blood type, on the other hand, lacks both A and B antigens and does not have the Rh factor. To produce O negative blood, both parents must have O negative blood type, ensuring that no A, B, or Rh antigens are passed on to the child.