| | Conditions & Treatments | Blood Disorders How rare is o negative blood? The distribution of blood groups varies around the world, however, O negative is usually one of the rarest blood types, accounting for about 7% of the population in the US. Blood Disorders - Related Articles High Blood Sugar Problems What Helps Clean Uric Acid From You Body? How to Tell If Someone Is Anemic? Can A negative blood be donated to plus blood? What are some examples of the different symptoms bleeding disorder known as ITP? What is the most numerous in human blood? Acidosis Symptoms