| | Conditions & Treatments | Arthritis Is arthritis autosomal or sex linked? Neither. Arthritis is a polygenic disorder, which means that it is caused by the interaction of multiple genes and environmental factors. Arthritis - Related Articles Acromioclavicular Joint Arthritis Pain Sources of Ankle Pain How to Prevent Trigger Finger Diet for Gouty Osteoarthritis Herbal Remedies for Arthritis-Related Spinal Spurs What to Expect at Rheumatology Appointment What are the symptoms of infectious arthritis?