Percocet Allergic Reaction: Hives, Anaphylaxis, and Emergency Response
Hives from Percocet (oxycodone/acetaminophen) may resolve in hours, but any systemic signs require immediate EMS:
- Angioedema (lips, tongue, throat)
- Wheezing, stridor, dyspnea
- Hypotension, syncope
- GI: vomiting, diarrhea
Emergency Treatment
- IM epinephrine 0.3–0.5 mg (EpiPen)
- IV antihistamine (diphenhydramine) + corticosteroid
- Airway support, fluids, monitoring
Carry epinephrine auto-injector if confirmed allergy. Avoid all oxycodone/acetaminophen products. MedicAlert bracelet recommended.
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