Breast Cancer in U.S. Women: Incidence, Mortality, and Impact

Breast cancer is the most common cancer among U.S. women (excluding skin cancers) and the second leading cause of cancer death after lung cancer. In 2021, estimated 281,550 new invasive cases and 43,600 deaths.

Risk factors: age, genetics (BRCA1/2), family history, dense breasts, reproductive history, hormone therapy, alcohol, obesity, inactivity. Screening mammography (starting 40–50 per guidelines) reduces mortality. Early-stage 5-year survival >99%.