Forehead Bump: 10 Differential Diagnoses & When to Biopsy

A persistent forehead bump warrants evaluation. Differential includes:

  1. Sebaceous cyst: Central punctum, mobile, keratinous content
  2. Lipoma: Soft, doughy, mobile, subcutaneous
  3. Dermatofibroma: Firm, dimple sign, often post-traumatic
  4. Skin tag: Pedunculated, fleshy, intertriginous areas
  5. Insect bite/sting: Acute, pruritic, resolves days
  6. Contusion/hematoma: History of trauma, evolves colors
  7. Epidermal/ganglion cyst: Firm, fixed to deeper structures
  8. Osteoma: Hard, fixed to bone, slow-growing
  9. Basal/squamous cell carcinoma: Pearly, ulcerated, telangiectatic; biopsy
  10. Melanoma: ABCDE criteria; urgent biopsy

When to Biopsy/Refer

  • Growth, color change, ulceration, bleeding
  • Size >6 mm, asymmetry, irregular borders
  • Patient immunosuppressed or high UV exposure

Dermatologist evaluation recommended for any concerning lesion.

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