Keflex (Cephalexin) for Dogs: Dosing Requires Veterinary Guidance

Cephalexin (Keflex®) is a first-generation cephalosporin antibiotic used for canine staphylococcal skin infections (pyoderma), among other indications.

Dosing Principles

• Typical range: 22–30 mg/kg PO every 8–12 hours.
• Duration: Minimum 3–4 weeks for deep pyoderma; 7–10 days past clinical cure.
• Weight-based: Exact dose requires current body weight.
• Renal adjustment: Reduce dose/extend interval if renal impairment.

Why You Need a Veterinarian

• Confirm diagnosis (cytology, culture)—not all skin lesions are staph.
• Select correct antibiotic (culture/sensitivity for recurrent/resistant cases).
• Determine dose, frequency, duration for your dog's weight, age, health.
• Monitor for side effects: GI upset, hypersensitivity, rare neutropenia.
• Address underlying causes (allergies, endocrine, parasites) to prevent recurrence.

Human vs. Veterinary Formulations

Human cephalexin capsules may be used off-label but require precise dosing. Veterinary suspensions (e.g., Rilexine®) are weight-calibrated and flavored. Never guess the dose.

Antibiotic stewardship protects your dog and public health. Always involve your vet.