Z-Pack (Azithromycin) and Urination: Side Effects and What to Expect

Urinary Effects

Azithromycin (Z-Pak) does not typically cause increased urination as a common side effect.

Common Side Effects

• Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
• Central nervous system: headache, dizziness
• Skin: rash, itching
• Taste disturbances

Rare but Serious

• QT prolongation (arrhythmia risk) – caution with other QT-prolonging drugs
• Hepatotoxicity
• Clostridioides difficile–associated diarrhea
• Allergic reactions (anaphylaxis, Stevens-Johnson)

When to Contact Your Doctor

• Severe or persistent diarrhea (possible C. diff)
• Signs of allergic reaction (swelling, difficulty breathing, hives)
• New or worsening urinary symptoms (pain, frequency, blood) – may indicate unrelated UTI
• Any concerning or unusual symptom

Take azithromycin exactly as prescribed. Complete the full course unless directed otherwise by your prescriber.