What Is Chronic Recurrent Multifocal Osteomyelitis (CRMO)?

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, inflammatory bone disease that affects children and adolescents. It is characterized by recurrent episodes of inflammation and pain in the bones, typically in the long bones of the arms and legs. The exact cause of CRMO is unknown, but it is thought to be related to the body's immune system.

Symptoms of CRMO can include:

- Bone pain

- Swelling and tenderness in the affected area

- Fever

- Fatigue

- Weight loss

- Skin rashes

Diagnosis of CRMO is based on:

- Medical history, physical examination

- Blood tests to check for inflammation

- Imaging studies such as X-rays, MRI, and bone scans

Treatment of CRMO may include:

- Nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain and inflammation

- Antibiotics if there is an infection

- Corticosteroids to reduce inflammation

- Immunosuppressive medications to suppress the immune system

- Surgery in some cases to remove damaged bone or relieve pressure on the nerves

CRMO is a chronic condition, but it can usually be managed with treatment. Most children and adolescents with CRMO eventually go into remission.