Electroconvulsive Therapy (ECT): Modern Practice, Safety & Indications
ECT has not stopped—it remains a gold-standard treatment for severe, treatment-resistant psychiatric conditions. Modern ECT bears little resemblance to historical depictions: it is administered under brief general anesthesia with muscle paralysis, using ultra-brief pulse, right-unilateral electrode placement to maximize efficacy and minimize cognitive side effects.
Current Indications (APA / NICE Guidelines)
- Major depressive disorder (MDD) with psychotic features, catatonia, high suicidality, or failure of ≥2 adequate antidepressant trials
- Bipolar depression or mania unresponsive to medications
- Schizophrenia with catatonia or treatment-resistant positive symptoms
- Neuroleptic malignant syndrome
- Severe autism-related self-injury (selected cases)
Treatment Course
- Acute series: 2–3 sessions/week × 6–12 treatments (individualized)
- Continuation/maintenance ECT: weekly → biweekly → monthly to prevent relapse
- Each session: 5–10 min procedure; 30–60 min total with recovery
Safety Profile
| Aspect | Modern ECT |
|---|---|
| Mortality | ~1 in 50,000 treatments (comparable to minor surgery) |
| Anesthesia | Methohexital or propofol + succinylcholine/rocuronium |
| Monitoring | EEG, ECG, BP, SpO₂, ETCO₂, EMG |
| Common side effects | Headache, myalgia, nausea (day of); anterograde/retrograde memory gaps (weeks) |
| Cognitive mitigation | Right-unilateral ultra-brief pulse; seizure threshold titration; interictal interval optimization |
