Ramipril & St. John’s Wort: Dangerous Interaction – What You Need to Know

Do Not Combine Ramipril with St. John’s Wort

Ramipril is an ACE inhibitor used for high blood pressure and heart failure. St. John’s wort is an herbal supplement often taken for mood disorders.

Why the Combination Is Unsafe

• Reduced effectiveness: St. John’s wort induces liver enzymes that accelerate ramipril metabolism, lowering its blood levels and diminishing blood‑pressure control.
• Increased side effects: The interaction can raise the risk of dizziness, lightheadedness, and headache.

Recommendation

Avoid taking St. John’s wort while on ramipril. If you are considering the supplement, consult your doctor first. They can suggest safer alternatives for mood support that won’t interfere with your cardiovascular medication.