Penicillin & Zyrtec Interaction: Safety & Risks - Doctor Advice

Consult your doctor. If you're allergic to penicillin, you should not take Zyrtec (cetirizine), as both can cause serious allergic reactions.

Penicillin

Antibiotic for bacterial infections. Take exactly as prescribed; complete the full course.

Zyrtec (Cetirizine)

Antihistamine for allergies (hay fever, hives). Generally safe but may cause drowsiness, dry mouth.

Allergy Warning

If allergic to penicillin, avoid Zyrtec. Symptoms of penicillin allergy: rash, hives, swelling (face/lips/tongue/throat), difficulty breathing, nausea, vomiting, dizziness, lightheadedness, seizures. Stop both medications and seek immediate medical attention if these occur.

Discuss your medical history and allergies with your doctor before combining these medications.