Nasal Decongestants in Pregnancy: Safety Guide

Preferred: Intranasal (Spray) Decongestants

Act locally with minimal systemic absorption. Considered lower risk:

• Oxymetazoline (Afrin, Dristan)
• Phenylephrine nasal (Neo‑Synephrine)
• Xylometazoline (Otrivin)

Limit use to 3 consecutive days to avoid rebound congestion (rhinitis medicamentosa).

Avoid: Oral Decongestants

Systemic vasoconstriction may reduce uteroplacental blood flow:

• Pseudoephedrine (Sudafed)
• Phenylephrine oral (Contac, some Sudafed PE)

Only if prescribed by obstetrician for compelling indication.

Non‑Drug Alternatives

• Saline nasal sprays/rinses (safe, effective).
• Humidifier.
• Elevate head of bed.
• Hydration.
• Avoid known allergens/irritants.

Key Advice

Always consult your OB‑GYN or pharmacist before using any medication in pregnancy. Individual risk‑benefit assessment is essential.